I noticed that during game updates (on the launch screen). The changelog generally contains a link to https://forums.flightsimulator.com.
When on this screen pressing the “A” button on an external Xbox controller opens the link. Unfortunately it does so even when the window (MSFS) is not in focus or even minimized.
This renders the controller unusable in other programs/games during the update process (which may be very lengthy).
In my opinion it would be nice for MSFS not to handle controller inputs (most importantly when out of focus) for these updates.