I am having the same problem and have done everything suggested above, my system:
AMD Ryzen 9 3950X16 Core 32 GB Ram 64 bit Nvidia RTX 3080 with windows 10
I was helped by Logitech support which only recommended the same suggestions above basically only using a USB 2.0 port and turn off the power management feature. After several discussions with Logitech support, they agreed to send me a new one. It arrived today and after 30 mins of fun play, it too disconnected. It has happened while playing MSFS and X-Plane 11. So now Im stuck with no answers. If anyone has found one please let me know