I get the feeling that some people are dismissive of this bug.
But it is a critical bug: These Medium Cargo missions are not optional missions that can be avoided: they are mandatory to move forward in the cargo-focused career. In fact, the user must complete 10 of these missions to obtain the Heavy Cargo Specialization.
This bug especially impacts XBox users, because they have a very hard time doing operations that require a mouse … many of us cannot do any action that requires a cursor. So, PC users who can easily “disable audio” or “manually program the flight plan” should bear that in mind before dismissing this as “not a bug”.