If you can find a left handed joystick…
I have used a joystick/keyboard/mouse control setup for 40 years.
Unless you have the budget and space to get a yoke and numerous quadrants/switch panels you will always find yourself reaching for a mouse for some of the panel knobs/switches. You can map most things to a keyboard command but the number of key combinations will often mean two hands.
Your ‘home cockpit’ setup will dictate the number of peripherals you have space for. Even with $1000s of dollars in add ons, you will eventually need to reach for the mouse.