Resolution versus Render Scaling

What would you think: does it make any sense to set the resolution to 1440p (rather than 1080p) with a 4k monitor? My GPU (AMD RX 5700) is way too slow for UHD. With FullHD (1080p) each rendered pixel equals 4 native pixels on screen. Would there be any benefit from 1440p in a visual sense? How about AMDs ability to sharpen the input? I really can’t tell by looking at the output :wink: