I am running a 2060 Super with a Ryzen 5 3600. I run most settings on high end so not sure what is causing your instability but I’m pretty sure it’s not from running on too-high graphics settings.
You mention you updated the GPU drivers. What version are you on? Seems like all of the drivers have their own host of problems lately but people seem to be having the most luck with 457.51.
Have you tried updating your BIOS? Could also try a clean boot to see if something in the background is interfering.