I do not use that software but can appreciate how powerful it is allowing you to do those things.
One thing that does not appeal to me at all is enabling just one area to fly in.
Unless Im mistaken - this would mean that if mid-way through a gaming session if I change my mind I would have to exit, enable the OTHER area I want to fly in and then restart the game.
I would rather have the entire game load each and every time so that anywhere on earth that I have addons will be available.
The load times of the game dont bother me, I just make a coffee 
and Im on a spinner drive. Many people are on SSD so the loads cant be that bad.
I do however see AOLs value in letting you rapidly enable/disable mods for testing purposes.
I do wish we can one day use Vortex as a mod manager, I really like that one.