I see this thread is a bit old but I also have a problem with the TDS GTNxi when in VR. I can load it and use it with no issue when in 2d mode but as soon as I put the Pimax Crystal headset on the TDS GTNxi 750 will not respond to any mouse inputs. Sometimes I can get it to load while in VR but no response to the mouse. If it does respond at all it can take several minutes and thus is unusable. I don’t recall this issue when using my Reverb G2. I too have reinstalled current TDS version, latest Nvidia driver for my rtx 4090 and emptied the community folder except for TDS GTNxi and the Just Flight Piper Arrow. Here’s another wrinkle, if I load it in 2d mode then put on the headset and select something in the TDS with the mouse nothing happens but when I go back to 2d mode the item I selected has activated. Anyone else experience this? Is there a fix?