One of the only times I crashed in the sim where I was not screwing around (like doing aerobatics in inappropriate aircraft or landing on mountaintops) was coming into Telluride in the Bonanza. I was about 1/4 mile from the end of runway 9, had the runway made, on speed, on the PAPI glidepath, got caught in a -600fpm downdraft and that was that.
I immediately retried the same approach a few more times and found I could only make it work if I was 200 feet or more above nominal glidepath, but combine that with a downsloping runway, those landings were waaay long.