I agree with @somethingbrite.
I do not know what the best way is to reset your profile, but I would try with the default MSFS bindings first and remove duplicate bindings from them to be on the safe side.
It is also true that peripheral disconnections could cause issues (they did at least in the past, although this should not be the case anymore as @somethingbrite said). For testing I would also recommend to directly connect your sidestick to your pc if this is not the case (especially no non externally powered usb hubs for example). Have the sidestick connected before starting the sim and do not disconnect it. If you sometimes hear the windows peripheral disconnection sound this would also be a strong indication for a connection issue.