Ed,
It is entirely normal that a game assigns axes to hardware control axes that it finds available at the PC. This is exactly what Raynen said 2 years ago: check your bindings. DCS, which was mentioned above, does that too. MSFS will assign the mixture to Z or Y or whatever axis and it will obviously interfer. Whenever you plug in a new hardware controller: check the hardware assignments and the first thing to do is delete them. The TDC controller is usually set to control the elevator and ailerons, obviously delete them. The zoom slider (actually friction in the A10) will have something as well.