So, I have an odd problem…
It seems that ever since I upgraded from a 3070 to a 3090, mouse clicking in VR (both clicking on instruments and the menus) often doesn’t work. Moving the mouse around is fine, but I’d say 70% of my mouse clicks in VR don’t work. I don’t have this problem in pancake mode.
I need to try a wired mouse to see if the new card is creating interference with my wireless mouse, but I thought I’d see if anyone else has had this problem.
When you start moving the mouse, close your right eye as you position and go to click. Mouse positioning is left eye dominant for some reason under VR. I understand a ticket has been raised to switch this to be right eye dominant. Because the cursor is so “close” to your face the parallax effect is massive.
Try that and see if it helps.
No, I’m used to the positioning issue. I have the item highlighted and it takes several clicks before it finally takes.
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X570 by any chance?
Yes, but the USB connection is via a PCIe card.
Wireless mouse is using onboard Bluetooth or it’s own dongle? if the latter is the dongle plugged into the Mobo or the PCIe card?
Have you tried disabling PCIe 4.0 in bios? Have you updated the bios recently and do you know what AGESA it’s based on? Later BIOSes should include some USB 2.0 stability fixes.
Whether it’s the increased power demand creating extra noise in the system or higher data rates causing trouble, I’ve seen all sorts of silly nonsense going on with the 3090 set to pcie 4.0 including, interestingly given your predicament, garbled and inconsistent Bluetooth audio.
It’s own dongle. It’s plugged into a powered USB hub off the mobo.
I haven’t disable PCIe 4.0 as I didn’t have any problems until now. I was on the latest BIOS until this last Friday as I see now they just release a new version on Friday. 
Before Friday it was on the latest non-beta driver. 
Ok, chances are that latest version is the non beta 1.2.0.0 AGESA version so worth trying if that’s the case as 1.2.0.0 did resolve some pcie 4.0 instability with the G2 for me (but not a total fix for other system oddities).
I would definitely try forcing pcie3.0 across the board, just see if it solves your problem… will save you barking up numerous wrong trees for the sake of a quick check.
Also worth trying the bluetooth dongle in the PCIe USB card slots.
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