If you want to dig into the keybindings and peripherals settings and issues, I would warmly recommend to have a look on a youtube Tuto (I am not affiliated blah blah blah) called “Tutorial #2 - Peripheral Control Setup - Microsoft Flight Simulator” from “Squirrel” account (sorry, cant post external links)
Excellent tuto, clear, easy to catch, go fully throught the option settings, including usual mistakes, really worth to take the time to look into. It maight help some of us struggling with the controls.
the guy is also offering other tutos which are really good. I am not in youtube things at all, dont like them usually, but this one, you should give a try.