I use the following peripherals from Virtual Fly: Yoko (yoke), TQ6 (throttle levers) and RUDDO (rudder controls).
After the SU5, the RUDDO (rudder controls) started to intermittently stop working for pretty long periods of time. It would start to work again suddenly in a completely random fashion and then stop again after a little while, and go through this on/off cycle for as long as I would play. It does it every single time I start a new MSFS2020 session.
The Yoke and the throttle still work perfectly.
PC: 11900k, RTX3090, 32Gb RAM
Nvidia drivers and Windows 10 up to date
Tested with empty Community folder
Issue started since SU5
Not using developer mode
No Zendesk ticket submitted