What are good fuel efficiency cruise settings for the DC-3?

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At 90 knots, PROPS are reduced to 2550 rpms, POWER is reduced to 40 inches of Manifold Pressure and MIXTURES stay at AUTO RICH.

At 110 knots, PROPS are reduced to 2350 rpms, POWER is reduced to 36 inches of Manifold Pressure and MIXTURES at AUTO RICH

At desired flight level or Cruise, PROPS are reduced to 2050 rpms, POWER is reduced to 30 inches of Manifold Pressure and MIXTURES are reduced to AUTO LEAN. Cruise speed here can be (depending on winds) up to 165 knots, indicated airspeed. (Wind only affects ground speed of course).

A further reduction can be made for longer flights at Cruise, PROPS are reduced to 1750 rpms, POWER is reduced to 25 inches of Manifold Pressure with MIXTURES at AUTO LEAN.

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