Yes*
*Enabling VR turns on separate graphics settings. You can see this along the top of the graphics options and just hit the arrow it’ll change to “VR.” So you basically have independant settings for flat screen and VR
Just remember whatever settings you had in flat screen has to be effectively rendered twice in the headset, one for each eye. Just because it runs in flat screen at 4K at 60fps doesn’t mean it will in VR. TLOD is a performance hitter for most systems.