@N582TC There is a little bit of cross-talk between 2D and VR in the sense that the size of your 2D mirror window directly affects the clarity of some things in VR, mostly flight plan waypoint icons and text on the world map, and point of interest icons and text when flying. That’s kinda crazy, but that’s the way it is.
For settings crosstalk there is nothing directly between them (other than DX11/12 choice) but you should make sure to have your terrain LOD, object LOD, and texture resolution settings perfectly matched. Same for buildings, trees, and grass to a lesser extent.
I haven’t tested using mismatched texture resolutions, but considering changing them requires a restart I doubt the results would be good. Using mismatched terrain LOD settings though means loading or dumping a ton of data each time you switch modes, which slows down switching and introduces stutters for awhile afterwards.