Which weather data can I believe

Yes this is the issue for me as well. Setup page shows winds for example 205 @ 05 so I select runway 20 for takeoff, for example, then I jump into the sim and the winds are 090 @ 08 and I’m stuck with my IFR flight plan taking off from runway 20. NBD when winds are mild, but taking off with a 25kt tailwind is no fun.