Sure, that’s how I fly all the time. On the world map screen pick your departure airport and either runway or parking spot load your plane and then use plane GPS to plan out your flight. Or if you’re flying vor to vor take off and use the radios to navigate. No different really from Xplane or P3D in that respect. If you’re looking for simbrief import features I think working title G1000 nxi and working title G3000 support that natively from simbrief Working Title CJ4 has that feature as well and for the defaults you need to export simbrief plan into a proper directory for it to get picked up.