Hi Mick. Would you consider an Intel and Nvidia build? I’m not a total expert as WristyLawyer suggested 
but used to build PC’s and from experience I found Intel builds performing better with less issues. AMD owners please correct me.
On the other hand, I’m starting to wonder now if there is hardware setup that will run MSFS trouble free. It seems that Asobo have still some work to make it a perfect experience.