To set up a basic route that the LNAV will follow:
[RTE], enter departure ICAO code into the ORIGIN field.
Enter runway number into RUNWAY field.
Enter destination ICAO code into the DEST field.
Click Activate, then [EXEC]
[DEP/ARR] x2 then select the ARR for the destination airport. Select an Approach, then [EXEC]
[LEGS] page shows the current flightplan. At this point you likely won’t have a magenta line on the nav display yet, as the LEGS page will have a discontinuity. To clear this, select the line below the disc to copy it, then paste it into the line above. Then [EXEC] again.
The Nav Display should now draw a magenta line.
(In the screenshot below I would click the button next to REBLI to copy it, then click the button on the line above to paste it).