Nope.
At high settings this sim is incapable of keeping stability with 16GB of committable memory or less. If you add another 16GB of virtual memory on top of your 16GB of physical for a total of 32GB committable, the crashes become temporary freezes or stutters instead. While less than idea, at least the application is able to run indefinitely. Alternatively you could lower settings until the memory requirement for prolonged use falls below the 16GB limit but that takes a bit more testing than setting a page file. You also get much less eye candy. Is that worth the stutters caused by swapping? Dunno.
The devs said that the upcoming updates will bring “2x the memory optimisation”. What exactly that will translate to in terms of memory footprint I have no idea.