yes and no 
In each game mods can cause lots of trouble. Therefore , at least for this time, the issue reports here assume “no installed” mods.
In case you report such a extrem behavoir , or CTD because of these, please be fair and mention at least then that you use the mod X and you also know that it comes from the mod
Example: Crash to desktop without error message - #3706 by aprodigyyy
The recommendations for some settings are of course also made for these assumption. We can not be aware of all mods ..
And how developers can made the “mod interface” more “bullet proof” , is out of what we know