Yes. But, only if I Continue a flight…
Start by creating a new flight, fly that flight, land, park & shut down.
Click Continue (when the option menu pops up).
While still in the cockpit, I program a new flight plan (pick local airport as departure and new destination airport) in the navigation system.
After getting IFR approval, taking off and that is when I usually enable AI Controls to take over the Radio.
Some times I cannot get IFR option from ATC on the ground. I take off then ask for IFR flight plan to continue. Still no AI Control for the radio.
I have tried the other options, AI Control to Fly or Checklist.
I do not have to restart the SIM to get it back. I exit to the main screen and start a new flight.