Like almost every other setting or tweak it is best to try it for yourself on YOUR system. There is no tried and true list of settings that will work for every person. There is such a large difference in hardware and software now a days it is just impossible to do. Same with bugs and glitches in games and the need for patches and updates for them. You simply can’t account for everything. Take for instance all the people that have trouble installing the game, or it crashing to desktop. When others like me have had 0 issues with this. Mine downloaded and installed just fine and has never crashed yet.
I tried just about every tweak I could find in the first week I had the game. Some work, some do nothing, some made it worse. Me personally, having game mode on helps. I get an extra 10 fps with it on. Will that work for you? I have no idea. Make a simple flight plan and run it taking notice of fps and performance. Then turn it on or off and take the same flight to see if it changes.