Joystick Ergonomics, Real Differences...?

Like much in life flight sim peripherals are a case of “buy once, cry once”

Sure there are plenty of mainstream plastic offerings out there which don’t have great components in them but are still asking quite a bit more than they are actually worth.

And then there are the smaller companies that rely on their reputation for design, component choice etc to sell stuff.
These tend to be a little more expensive but are longer term investments which will serve you longer.

For the basic desktop joystick which includes a throttle on the base type experience I would recommend the VKB Gkadiator NXT.

Good design and quality components throughout.

For grip ergonomics.
I have both the Virpil MT-50 military grip and a Virpil Constellation Alpha which is a little bit sci-fi looking space sim grip.
To be perfectly honest the ergonomics of the Alpha are really good. It’s just really comfortable to have in the hand for a long time. The MT-50 is a bit less chunky and I felt the need to wear a glove when flying for extended periods.

For general ergonomics.
Once you have the ability to do so, lower the height of your joystick. Your shoulder should be relaxed and your forearm not higher than your elbow. For ultimate ergonomics forearm resting on thigh almost with the stick between your legs.

When you get to this point you will be looking for the HOTAS (hands on throttle and stick) type set up where you have a separate throttle set to one side.
Again. This should be set low enough to be comfortable.

I’ve got the same Logitech as you kicking around somewhere. I found it a bit angular and not so comfortable.

I have also been through a few Thrustmaster T16000’s. The ergonomics are a bit better. Not great, but ok. However the component choices and reliability are quite poor. The buttons are all very mushy and the cheap potentiometers fail quite quickly.
(Once you have bought a couple of those you might as well have paid for a VKB or Virpil)

Extended ergonomics.

I flew for a pretty long time using the twist grip function for rudder/strafe but if you do it for too long or the adjustments are small and fiddly the wrist gets a little more strain than might be desirable.
Improvement to ergonomics here would be to forget the twist altogether and go with rudder pedals.