I recommend editing usercfg.opt file and changing DX11 to DX12.
To do this, you need to edit usercfg.opt file and modify the line
PreferD3D12 0
Change the number 0 to 1
and save the changes.
It looks like Asobo has already fixed the CTD during loading MSFS 2020 with DX11 in the latest beta version. More details can be found in the thread linked below.
bug-logged https://forums.flightsimulator.com/t/msfs-2020-ctd-during-loading-with-or-without-nvidia-app-installed-dx11/732584/162?u=tenpatrol