MSFS Application Error - memory could not be read

Add me too to this Application popup: EDIT Today 2 flights and 2 CTD after ca 1 Hour flight
Microsoft Flight Simulator - 1.27.21.0: FlightSimulator.exe - Application Error : The instruction at 0x00007FF70B55FD44 referenced memory at 0x0000000000000010. The memory could not be read.
Since today I am experiencing this. Yesterday I flew 8 hour in total and not one time this issue. Since today this is popping up in at least every second flight (mostly my flightdureation is between 01:30 und 02:30 hours. The errors popped up in the first hour after round about 1 hour.
Using VR with Varjo Aero and OpenXR Toolkit
System specs

Edition Windows 11 Home
Version 21H2
Installed on 20220717
OS Build 22000.978
Windows Feature Experience Pack 1000.22000.978.0

Nvidia Driver Latest Stable

i9 10900K @ 5.0 Ghz | HT OFF | 1.32V
Mainboard ASUS ROG Maximus XII Formula Z490
32 GB RAM 3600 Mhz Corsair Vengeance | 4x8GB
RTX 3090 24GB
32" Samsung UHD Monitor using 4k
Custom Water Cooling | 2x 360MM
Varjo Aero | Varjo Base
HP Reverb G2 VR HMD | Steam VR

Main MSFS Addons

Fenix A320
FBW Experimental Mode
FSCrew
FSLTL
AIGAIM | Latest Version
AIGTC | Latest Version (Not in Use)
+160 Addon Airports | Incl. 5 CityPacks

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