I have the 3080Ti, and I recommend
AA- DLSS Super Performance
Frame generation - off
AMD Sharpening - 0
Resolution 1080P
Other settings - Mostly on High
Terrain LOD - 150
Objects LOD - 150
DirectX 12 (Beta) - switch back to DX11
Hardware and graphic acceleration - ON
Game Mode - ON
Nvidia settings - set high performance for MSFS and changed filtering to X16. This is an urban myth. There is only one Anisotropic filtering. Set this in the game settings.
Set Texture Resolution to LOW.
Set Nvidia Reflex to On + Boost.
Turn down the shadows and reflections.
Turn off Ambient Occlusion.
Turn on Bloom.
Restore Nvidia Control Panel to defaults and set Max Framerate to 45fps.
I hope this helps.