Could it be because of conflicting software?
Turns out there is a conflict between MSFS and Capture One. Who would have thought to test that!?
If you’re a Capture One user, please read this thread. TLDR - there is a DLL that MSFS appears to be loading and causing CLR.dll and other errors. Who knows what other software could also be causing similar errors.
Read this post…
CTD caused by Capture One 20 codec - Bugs & Issues / CTDs - Microsoft Flight Simulator Forums