Ditto what CasualClick & Seven7Tango stated.
Disregard the Performance Guide, it’s biased towards shooters and such, means nothing for msfs, other than showing you frame rate.
Most of the default settings are aimed for first person shooters, etc. and dx9 improvements.
Any settings that have amd or use application settings options are set to application.
note. 21.12.01 are the newest that work for me, all 22.xx.xx cause ctd for me.
1440p monitor 30 vsync for me set in msfs.
Good idea on drivers only Seven!