I use MSFS2024 and have always used reshade without a problem.
I needed to reinstall MSFS 2024 today, and reinstalled reshade.
No problem other than some message about small default stack size which I have never had before.
But Reshade still worked.
But then when I came to run the sim again, all my settings had reset to default, keybinds for toggle, screenshot locations and keybind for screenshots etc., etc.
And the preset wasn’t loaded in and I had to select it again.
This is now the same on every restart of the sim.
Anyone have any idea what is going on?