Maybe it is weird to suggest, but have u tried with renderscale 65% to set multisampling an anisotrophic setting off in ui general setting, for sidenote says taa below 100% and above 100% anisotrophic will work as upsampling i dunno if it the same in beta.
If change secondary scale in usercfg.opt set at 0.800000 or lower then renderscale can be cranked up and there for the balance would be shifted, so you would be at let say 120% of render and you would/should benefit Upscale with anisotrophic and supersample.
It could be i interpretate this the wrong way but i have pretty good result imo with previous sim updates
Anyway in this way huge screens should get performance and quality profit