Do you have the same issue if you follow the OP’s steps to reproduce it?
Yes
Provide extra information to complete the original description of the issue:
I noticed this in my career too where no new missions appear in areas you clear on the map. I can’t fly in the south of UK anymore because its empty as well as other areas I’ve cleared.
https://forums.flightsimulator.com/t/career-missions-dont-respawn-refresh/677868