This does not seem to be a GPU issue or at least it’s not GPU ONLY. My GPU works absolutely fine with all other games except MSFS. Before the latest sim update 3 there were no issues with this GPU using the exact same drivers and settings. I was getting other CTDs but never vcruntime140.dll errors. This is something that began after the latest MSFS update. And like I said it disappears as soon as I start using manual tuning settings.
More examples: AMD Radeon RX 6900 XT driver crashes after world update 3 - #12 by TheSevenflyer