because of that amount of RAM at first you should possible check your windows virtual memory setting ( pagefile ).
Please set is to a manual size of : minimum:8GIG maximum:20GIG ( betterr 30GIG) ( 8000 / 30000 ). Please also ensure there is enough free space on your disc.
See also:
In case this will not be helpfull, can you please check the windows event log for an error entry ?
Related to AMD you mention, it might be helpfull you mention then also your current driver version.