If you go by the devs that wrote it, leave it alone unless you are running a server farm. If you want to follow gamer snake oil, change it. Then probably complain about having an unstable system. It is not just for memory overflow situations as many like to think.
I played with it many times over the years and never got a reproducible improvement o since FSX, I never touch it. Though I know others will probably claim great benefits.
So if you do change it, and you do have stability issues in the future, try to remember to put it back to system manager.