Hello!
This happens on different aircraft (PMDG, Fenix,…)
The mousepointer changes into a double headed arrow (it looks like the windows mouse pointer when you change the size of a window) and hides the clickspot behind it. When I change the view a little bit most of the time it works again. The arrow does not only appear over clickspots, it also appears randomly over Virtual cockpit parts without clickspot.
See my short YouTube video where you can see the arrow: https://www.youtube-nocookie.com/embed/oli14sQr3zU
So far I checked mouse drivers, tried another mouse and checked some settings in MSFS but with no success. Is this a known thing?
Thank you!