I was able fix the x80000003 exception issue on my PC by setting manage virtual memory to automatic. Hopefully this change resolves it for you too. Here’s how:
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From the Search bar type Performance.
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Choose the Adjust appearance and performance of Windows. This will pop a Performance Options window.
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Click on the Advanced tab.
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Click on the Change… button in the Virtual memory section.
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Check the box Automatically manage paging file size for all drives
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Click OK
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Reboot your computer
Flight Simulator 2020 works great after this change!