OK, I finally got some answers. The problem exists because of Bitlocker. The solution for me would be to disable Bitlocker. Not going to happen.
He told me an alternative that will work. In G-Hub, create a duplicate copy of the Desktop profile and name it MSFS. Change one of the buttons to switch profiles. Change the other buttons’ function as needed for MSFS. So far, this is working for me. I just to have to remember which profile is active. There is a G-Hub notification-popup whenever the profiles change.