We already have a forum topic about this bug - CTD during MSFS 2020 loading. Here’s the link to the thread:
There’s currently a workaround available and even several of them.
Before trying any workaround, please make sure to participate in the linked thread to confirm you’re also affected by this bug.
Here come the workarounds (click to expand)
Until Nvidia fixes the application and Asobo MSFS 2020 please check what happens if you select DX12 instead of DX11 by manually editing cfg file.
To do this, you need to edit usercfg.opt file and modify the line
PreferD3D12 0
Change the number 0 to 1
and save the changes.
OR
If you need Nvidia app also select DX12
OR
If you need NVIDIA app and want to play with DX11, delete NGX folder - you’ll find it in C:\ProgramData\NVIDIA.
OR
If you don’t need NVIDIA app and want to play with DX11, uninstall NVIDIA app and then restart PC.
FYI, If you want to use the latest Nvidia drivers starting from version 580.88, DX12 must be selected in MSFS 2020 settings. With drivers newer than 577.00, there will be CTDs if MSFS is running in DX11 - even without the Nvidia app. If you use driver version 577.00 or older and want to play DX11 in MSFS 2020, the Nvidia app should not be installed.
Below is a step-by-step guide on how to uninstall and reinstall the NVIDIA driver.
Uninstall Nvidia driver using the DDU program in Windows Safe Mode.
1 Download Nvidia driver 577.00
https://www.nvidia.com/en-us/drivers/details/250997/
2 Download and install DDU
3 Unistall Nvidia driver using DDU in Windows Safe Mode.
How to use Display Driver Uninstaller (DDU) Guide / Tutorial | Wagnardsoft
4 Restart PC
5 Install Nvidia driver without Nvidia HD Audio and Nvidia app.
6 Restart PC