I use Acronis True Image 2020 as one of my backup solutions. That includes “Active Protection”, an anti-ransomware feature that attempts to detect software doing naughty things, and if so blocking them from running while asking the user if it’s OK or not.
What I think it does is inspect the code run by every process in real-time, which would explain the performance loss.
Windows Defender does not have this issue; I couldn’t measure any difference whatsoever having real-time scanning on or off there. Not sure about other antivirus/antimalware software, but anything that does active scanning could have an impact.
How much, you ask? Well…
I’ve repeated the tests several times, and indeed they’re repeatable. You can even try it out standing still on the runway; I instantly lose about 20-25 fps as soon as it’s active, and get them back as soon as it’s disabled again.
So in my standard benchmark run, it costs me an average of 27 fps! And that’s with a fast CPU (Ryzen 5800X). I can only imagine what would happen if you try to fly the A320 on an older CPU with something like this active and eating precious CPU time.
If you’re CPU limited and stuck at 25 fps, getting the same percentage gain would move you from 25 to 39 fps!
Similar software is likely also the cause of some stuttering issues. Excluding FlightSimulator.exe or excluding the MSFS data directories can probably help a fair bit for some, as I/O performance can be totally crushed by that. I had a case where an app was slow to uninstall (took about 15-20 minutes, and I had to redo it several times to troubleshoot an issue), but when I disabled Windows Defender’s realtime scan just while uninstalling, it took less than a minute every time.