From the OP’s description it is pretty clear now that this is not an issue with the device itself but with the simulator not saving the settings. So it is the simulator causing the problem or some windows admin rights stuff preventing the settings adjustments get written into their file.
There are several threads mentioning this issue.
I would like to add i am encountering the exact same issue with the Tflight Hotas X also on the supported list. It is quite frustrating because I can see the reverse checkbox working when clicked however the act of saving and coming back breaks it somehow. The box still is checked when returning but the throttle is still wrong and didnt change. this wouldnt be an issue if the checkbox actually worked
Still no resolution found. By the sounds of it. There is a an issue with the profile not saving.
I have a techy mate that is going to try help me find a solution. Will post an update if anything is found.
So, After spending some time with a friend. It was discovered that the issue had been already resolved.
I don’t exactly know what happened. I had a couple of flights were the control of the throttle was inverted. Caused me to crash into a couple of terminals at startup. So i was under the impression that it was part of the controls. Never bothered loading back into a plane to test the throttle. He noticed that his throttle inputs were doing the same as mine. Once I had loaded into a plane. The throttles operated as intended.
Not exactly sure why I had the original issues. Thank you to everyone that tried to help me resolve this.