Connect switch and radio panel to USB 2.0
edit
or buy USB 2.0 Rear Panel Bracket and connect to JUSB1 or JUSB2
https://www.amazon.com/Motherboard-Cable-2-Port-Bracket-Adapter/dp/B00AAZ4NH6
edit
Also go to BIOS settings
disable - XHCI hand-off
enable - Legacy USB suport
Save changes
I hope you get this working. I spent the day fiddling with spad.next as I had to decide whether to buy it and in the end I found it almost essential to get the most out of the three logitech panels which were too unreliable without it and didn’t work with many payware planes. Once I uninstalled the logitech driver and only used spad.next it was a lot more stable. If you start spad.next in “admin” mode it will automatically fix issues in Windows where it powers down the panels sometimes.
Hi,
Sorry to butt in but I use these panels with SPAD.
When you say they don’t work, can you expand upon that? I’m making the assumption that you know how SPAD works, have a configuration loaded for them that is known to work for a given plane you wish to fly, are aware of the panels foibles with regard to advanced power management, and have run SPAD elevated so it can disable this.
if MSFS is running ( e.g. in Menu ) , can you see the Logi…exe in Taskmanager ?
Thanks for this very indepth post, I will have a look at this later this evening. 
I think I really need a hub too, because I have many USB devices which need to plugged in:
Radio Panel,
Saitek Yoke (hoping to upgrade to an Alpha in the future),
Additional Throttle,
Switch Panel,
Rudder Pedals,
ButtKicker, and
VR setup…
I might be a little Flight Sim obsessed…
I have SPAD as well, and while this worked prior to upgrade, now they do not. Its like they are not recognized by the sim, because they are recognized by SPAD and the logitech test software. How ever, when in the Sim, the LEDs do not light up in the Radio Panel, and the siwtches, gear, and led do NOT work on the switch panel either. This evening, I will try @TenPatrol’s fix/work around.
fully agree with all of that devices you have connected.
But I not assume, and therefore I asking about the Logi…exe , that it is caused by a setting in BIOS. If that would be the case, why do the Test-Software show you the device ? But, lets see whats happens…
EDIT: by the way, my decices are connected on a powered USB3 hub… so, there are no issues with USB3 and it not need USB2
I have seen this many times. What I’ll typically see is that the back light for the multi-panel is on, but I see no text in the display. I have to power cycle them all, then power them on again, and only then run SPAD. That sounds like the advanced power saving getting in the way, or they are connected to an incompatible hub.
All my sim gear runs through a single 16 port powered USB hub.
SPAD can detect if power saving is enabled on the ports that having the Logitech gear connected, and will disable that, but it must be run elevated i.e. admin rights. There is also a small DOS program that can do this. The official site that hosted it has been down for some time I believe, but I had shared it via cloud storage some time back, so would need to dig out the link for that.
I’ve never had to do that before my new motherboard, seems way more painful than it should be
I’ve ordered a new USB2 powered hub which I will plug into a specific USB2 port, and hopefully that gets things working.
I’ve also turned that feature off in Windows10.
Even if SPAD is not run elevated, if enhanced power management is detected for the ports your Logitech panels are plugged in to it will tell you in a pop up window with lots of red text! If you aren’t seeing that, and SPAD can see the devices okay, then I guess you have it disabled. If the devices are seen by SPAD you should be able to see the little graphical images of rotary knobs move as you rotate the physical knobs.
My setup is all USB3, so that may not be the issue. From the sounds of it you don’t have a USB hub of any kind currently, and are plugging them directly into the motherboard, so that rules out that line of troubleshooting.
For the record, this is the hub I use:
https://www.amazon.co.uk/gp/product/B08FDRZPDL/ref=ppx_yo_dt_b_search_asin_title?ie=UTF8&th=1
@Zeanuck try USB Enhanced Power Manager Disabler
Download USBEnhancedPowerManagementDisabler.zip
Scroll down and click application
Unpack
Right-click USBEnhancedPowerManagementDisabler.exe and select run as administraor
Unplug all devices and plug them again.
Restart PC.
Edit
If spad.next installed - uninstall logitech plugins and restart PC.
Important info.
Please note, in the activation process the license will be hardware-locked to the computer you are activating the license from. If you need to move the license to another computer OR make hardware changes to your computer, you will have to invalidate your license before you can activate it again.
Narrowing it down… Now it seems the plugin won[t load…
The Logi…exe doesn’t want to run for some reason… 
EDIT: Sorry this is not what I see, the plugin will NOT load…
that looks normal unless it says not responding next to it.
nothing loads onto your screen just loads the plugin with the flightsim.
This any use:
thats why I asked 
There are different things you can try then:
@DORRAGER that looks like my screenshot with a running exe you see in former post
So I found the file, but when i ran it, I get a “No arguments use --help for argument list” error…???
ah, I checked the desktop link which the Logitech installer created and the existing exe.xml
Start-Link:
C:\Program Files\Logitech\Microsoft Flight Simulator Plugin\LogiMicrosoftFlightSimulator.exe --run --force
%AppData%\Microsoft Flight Simulator ( Steam ):
<?xml version="1.0" encoding="Windows-1252"?>
<SimBase.Document Type="SimConnect" version="1,0">
<Descr>SimConnect</Descr>
<Filename>SimConnect.xml</Filename>
<Disabled>False</Disabled>
<Launch.Addon>
<Name>Logitech Microsoft Flight Simulator Plugin Steam</Name>
<Disabled>False</Disabled>
<Path>C:\Program Files\Logitech\Microsoft Flight Simulator Plugin\LogiMicrosoftFlightSimulator.exe</Path>
<CommandLine>-r</CommandLine>
</Launch.Addon>
</SimBase.Document>
Have you already tried to run the Logitech Installer again ? Somewhat goes seemingly wrong at your PC.
UPDATE: Just received my new powered USB hub, plugged it all in…. Still nothing, no go. I have tried everything, and I mean everything, I am at a total loss at this point???
Does anyone have an older driver that might work??? Anything?
I still get that error:
PS: Not using steam, using MS Store version.
If you’re using the saitek yoke it has 3 usb2 ports on the side. Try those. It’s not like the data rate for switch panels is all that high, so you can safely add a couple of radio boxes and a second flight quadrant, or even a joystick/ HTH
Yup tried that too, and even upgraded to windows 11 thinking that might work…. Oh and when I run the test panel software, the panels found and working…. Just not in Fight Simulator.