I just reinstalled the sim this AM. I have nothing but the default Base, Deluxe, Premium Deluxe, WUs, and CUs installed (I disabled all the 3rd party Marketplace content the sim automatically enabled upon reinstallation. See: Freshly Generated Content.xml Enabling 3rd Party Content by Default - Bug Reporting Hub / Install, Performance & Graphics - Microsoft Flight Simulator Forums).
I was sitting at the included hand-crafted KSFO in the A310 and went to change the graphic settings for testing purposes. I clicked the Global Rendering arrow, which set the settings to “Low-End”. This produced a pop-up message about changing the settings and offered me the option to cancel. I clicked cancel and the screen went black and the sim CTD.
Fault bucket 1725451409248833406, type 5