There’s nothing you absolutely need to do unless you plan to overclock or undervolt. When you install Adrenalin, you’ll have options for driver only, minimal, or full version. Drivers only is just that with no configurable options. Minimal gives you some options, but I can’t remember off hand if it allows tuning. I run the full version so I have access to Adrenalin’s built in screen recorder. It’s largely user preference, but I’ve seen some people say the driver only version is the most stable and many problems are related to Adrenalin features. I have a 6600XT, and the only problems I’ve seen are when I push my overclock too much. Lol.
For overclocking and undervolting, Adrenalin has a couple of automatic options for this, but it’s pretty conservative. In my case, I can do either one or the other, but this may be card specific. If I try to undervolt plus overclock, it will override the undervolt setting and run at stock voltage anyway. Even with a very mild OC.
If you do overclock, I would suggest looking up tutorials on how to do it with your specific card. It seems not all AMD cards respond to MSI Afterburner, ironically including my MSI 6600xt. Lol. The most common method is to OC the memory first until that is fully stable, then work on the core speed. In Adrenaline you’ll see a minimum and maximum core speed. You’ll set your OC based on the max core speed, with the minimum set to 100 MHz lower. This only happens when the card is loaded in gaming or benchmark loads, so don’t worry about it running full tilt at all times.
If it’s not responding to Afterburner but you prefer to use it, then tune your OC with Adrenalin first. With a benchmark or game running to get the card loaded, go into Afterburner and save a new profile. That will capture the current settings in the GPU, and then you can load it later if needed. This would also mean you can uninstall Adrenalin to drivers only if you want, but you’ll have to re-install it if you need to tweak again.
Again, this is all general advise that may not apply to your card since they occasionally change things around. Verify this for your card if you plan to tune it manually so you get optimal settings. Also mind your temps! An OC means nothing if the card is thermally throttling lower. In some cases you may get better performance with undervolting due to the reduced heat load.
And I almost forgot, you’ll want to turn on Smart Access Memory now that you’ll be on AMD for both CPU and GPU, which improves memory performance. If that option is greyed out in Adrenalin, you’ll need to go into the motherboard BIOS and turn on Resizable Bar.