VR COM problem using VSR with 3 monitors

Using 3 monitor has worked fine until today. For the first time I used VSR in VR, I lost COM on all frequencies with Vatsim and the mouse cursor wouldn’t move to the left or Right monitor screens where I had VSR and vPilot open. Does this mean I need to only use one monitor before entering VR using VSR or is it a switching of speaker/mike problem with HP Reverb G2? Anyone else had this problem