Are you on Steam or Microsoft Store version?
Are you using Developer Mode or made changes in it?
Brief description of the issue:
CTD in VR mode + corrupted ROLLINGCACHE.CCC file makes it impossible to start the sim. Safe mode doesn’t help.
Detail steps to reproduce the issue encountered:
Got the CTD while in game. When trying to restart the sim the safe mode choice window appears, but no matter whether the safe mode is selected or not, the sim crashes to the desktop a few seconds after pressing a corresponding button.
Using the Process Monitor it can be seen that the last file access attempts in the C:\Users<username>\AppData\Roaming\Microsoft Flight Simulator folder point to the contents of the DCE subfolder and to the ROLLINGCACHE.CCC file.
Removing the ROLLINGCACHE.CCC file fixes the issue, and the sim can be used again.
Build Version # when you first started experiencing this issue: