I have a PC that is littered with SDKs of various languages (C#, VB, Perl, Python, SQLLite, Unreal, yada yada); a couple versions of MS Office (2010, 2013); three versions of Visual Studio; around 150 installed games (>100 on Steam alone); dozens upon dozens of apps from many companies (iTunes, Google Earth, Photoshop, Garmin, FiiO, Comodo, AVG, Splashtop, Firefox, Chrome, Putty, Blender,…); several DosBox programs and a few emulators; Uplay, Epic, Steam, Origin, GOG, Rockstar launchers; numerous symbolic links/junctions; and, apart from a recent series of CTDs where I’d accidentally deleted my pagefile (I was moving it from one partition to another - did I mention I have >9 partitions across 6 drives?!), I’ve not experienced any real issues with MSFS 2020 even when running multiple applications - hell, I’ve even been defragging, ripping CDs, updating Steam games, and such, whilst running MSFS (and alt-tabbing between them whilst doing so). And I’m ‘only’ running an i5-9600K and a RTX2060S with 16GB of RAM