Sounds like a problem I had with my T16000 a while back New computer new Windows 10, new MSFS2020 install crash to desktop with USB joysticks plugged in - #6 by Hotdognz MSFS worked great except when you plugged the joystick in, whereupon it would crash with 100% consistently. Appears to be a broken synced joystick configuration file, the app can’t make sense of it and gives up. Reinstall doesn’t work because it’s redownloaded from the cloud.